What Are The Top Anti-Aging Peptides Available on the Market?

Peptides are short chains of amino acids that act as building blocks of proteins, such as collagen, elastin, and keratin, found in various skin care products.

These proteins are the foundations of your skin and contribute to its texture, strength, and resilience by interacting with your skin cells. As we age, our bodies produce less of these vital proteins, leading to wrinkles, sagging, and dryness.

What are anti-aging peptides?

The anti-aging benefits of peptides are linked to their ability to signal the body to produce more collagen. When applied topically, they can penetrate the top layer of the skin and send signals to our cells to let them know how to function. One of the most important messages they deliver is to produce more collagen.

Certain peptides also block the release of neurotransmitters, which reduces the movement of muscles and, therefore, the appearance of wrinkles. This works in a similar way to Botox, but without the need for injections or the risk of side effects. 

Moreover, some peptides have an anti-inflammatory effect that can help with skin conditions like rosacea or chronic redness. By reducing inflammation, they promote healthier and younger-looking skin. 

In summary, peptides are a valuable tool in anti-aging skincare due to their ability to boost collagen production, reduce muscle movement, and soothe inflammation. Let’s have a look at which are the best anti-aging peptides.

What are the Benefits of Using Anti-Aging Peptides in Skincare Products?

Using anti-aging peptides in skincare products can help boost collagen production, improve skin elasticity and firmness, reduce the appearance of wrinkles, and enhance the overall health of your skin texture. 

Peptides are known for their ability to target specific skin concerns, reinforce the skin barrier, and promote a more youthful complexion.

Anti-aging Peptides

There are hundreds of peptides on the market, but only some can provide anti-aging benefits. Below is a small selection of some of the most popular research anti-aging peptides available today:

Sermorelin

Sermorelin peptide is renowned for its anti-aging benefits, primarily due to its ability to stimulate the production of human growth hormone (HGH). This increase in HGH can assist in reversing some effects of aging, enhancing energy levels, and improving muscular mass, contributing to overall well-being.

Sermorelin anti-aging peptide therapy has been associated with enhancing sexual function and libido in men and reducing symptoms related to aging such as fatigue and weakness. By boosting the body’s natural HGH production, it promotes a more youthful appearance and vitality, making it a popular choice in anti-aging treatments [1]. Check out Sermorelin peptides today from Direct Peptides.

SNAP-8

Snap-8 Peptide, also known as Acetyl Octapeptide-3, is a powerful anti-aging agent that targets wrinkles and expression lines. Composed of eight amino acids, the anti-aging peptide functions as a muscle contraction inhibitor, reducing the formation of lines caused by facial expressions. 

Its mechanism of action is similar to Botox, but it’s a safer, cheaper, and milder alternative that works topically. It is considered an advanced version of Argireline, another popular anti-aging peptide. Studies have shown that Snap-8 can reduce wrinkle depth by up to 38% within one month of treatment, making it a potent ingredient in anti-aging skincare [2]. Explore Snap-8 peptides from Direct Peptides.

CJC-1295

CJC-1295 research peptide has shown promising anti-aging benefits due to its ability to stimulate growth hormone secretion. This anti-aging peptide aids in improving skin elasticity and increasing collagen production, resulting in a more youthful appearance. Moreover, it can boost muscle mass and strength, which are often compromised with aging. 

Other benefits include enhanced metabolism and energy, decreased body fat, and an optimized immune system. Some studies also suggest that CJC-1295 may improve sleep quality, contributing to overall well-being and healthy aging [3].

Direct Peptides has CJC-1295 DAC and CJC-1295 no DAC peptides available in pre-mixed pens, vials and nasal sprays.

Ipamorelin

Ipamorelin Peptide is gaining attention in the scientific community for its potent anti-aging benefits. This peptide, composed of five amino acids, stimulates growth hormone production, providing an anti-aging boost. It’s known for combating and even reversing some aging symptoms. Benefits include increased lean muscle mass, fat loss, improved energy, enhanced brain focus, and joint health restoration.

Ipamorelin peptide is available from Direct Peptides . Furthermore, Ipamorelin aids in collagen synchronization which helps maintain skin firmness and elasticity according to clinical studies. Regular use has shown to increase collagen production, reduce wrinkles, and improve skin tone, making it a promising solution in anti-aging treatments [4].

Epithalon

Epithalon peptide is renowned for being anti-aging peptide for it’s fantastic benefits, primarily through its action on telomeres, the protective ends of chromosomes. By activating the natural production of telomerase, an enzyme responsible for maintaining telomere length, Epithalon prevents telomere shortening, thereby slowing down the aging process.

Discover Epithalon today from Direct Peptides. This anti-aging peptide can also rejuvenate skin health and repair damaged cells. Studies have found the anti-aging peptide to be effective in treating age-related hormonal imbalance by increasing melatonin production. Epithalon also helps to delay age-related diseases, boost energy levels, and promote deeper sleep. Animal studies have even shown increased longevity and prolonged eye retina integrity.

FOXO4-DRI

FOXO4 DRI Peptide from Direct Peptides is renowned for its anti-aging benefits, primarily through combating senescence, the age-related decline of cells. This peptide plays a crucial role in delaying aging and assisting the Insulin Signalling Pathway. It’s also been successful in removing “broken aging” cells, promoting hair growth, and potentially improving osteoarthritis treatments. 

Furthermore, FOXO4 DRI can reduce side effects of cancer treatments by selectively inducing apoptosis of senescent cells. Studies on naturally aged mice have shown increased health and energy levels. Overall, this anti-aging peptide bears potential to promote longevity and suppress tumour cells [6].

NAD+

The anti-aging peptide NAD+ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme present in every cell, essential for core biological functions like DNA repair, energy metabolism, and cell communication. As we grow older, NAD+ levels typically decrease, potentially accelerating aging and related diseases. Increasing NAD+ levels has been linked to various anti-aging advantages, such as better cellular performance, heightened energy, and enhanced ability to withstand stress and damage.

Several studies have shown that increasing NAD+ levels can promote healthier aging by activating sirtuins, a group of proteins that regulate cellular health and longevity. This has spurred interest in NAD+ precursors like Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN), which can help replenish NAD+ stores in the body. Consequently, NAD+ supplementation and its precursors are gaining popularity as potent components in the quest for anti-aging solutions [7].

MOTS-c

MOTS-c is a peptide derived from mitochondria that has gained attention for its potential as an anti-aging peptide with metabolic health benefits. It helps regulate mitochondrial function and cellular metabolism, which can lead to better energy production and endurance. MOTS-c promotes insulin sensitivity and improves glucose metabolism, making it a promising option for tackling age-related metabolic decline.

Additionally, this peptide may aid in healthy weight management by encouraging fat loss while preserving muscle. Research indicates that MOTS-c could also help reduce oxidative stress and inflammation, supporting its role as a new candidate for anti-aging peptide therapies. As interest in MOTS-c increases, ongoing studies are looking into its full potential and therapeutic uses in aging and metabolic health.

Overall peptides can provide a multitude of anti-aging properties. Whilst Direct Peptides supplies a number of anti-aging peptides it is important to note they are for research purposes only.

Explore our extensive collection of peptide vials at Direct Peptides , available for purchase online. Our broad selection caters to various research needs, offering multiple formulations for enhanced flexibility in scientific studies. Our catalogue also features a variety of non-invasive nasal sprays. Discover the perfect solution for your research requirements today.

References:

[1] Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging. 2006;1(4):307-8.

[2] Errante F, Ledwoń P, Latajka R, Rovero P, Papini AM. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Front Chem. 2020 Oct 30;8:572923.

[3] Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805.

[4] Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020 Mar;9(Suppl 2):S149-S159.

[5] Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, Zavarzina NY, Semenchenko AV, Yashin AI. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202.

[6] Le HH, Cinaroglu SS, Manalo EC, Ors A, Gomes MM, Duan Sahbaz B, Bonic K, Origel Marmolejo CA, Quentel A, Plaut JS, Kawashima TE, Ozdemir ES, Malhotra SV, Ahiska Y, Sezerman U, Bayram Akcapinar G, Saldivar JC, Timucin E, Fischer JM. Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells. EBioMedicine. 2021 Nov;73:103646.

[7] Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D’Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K, Menzies KJ, Auwerx J. NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science. 2016 Jun 17;352(6292):1436-43.

[8] Kim KH, Son JM, Benayoun BA, Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metab. 2018 Sep 4;28(3):516-524.e7.