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AMKP, or Adenosine Monophosphate-activated Protein Kinase, is a peptide involved in cellular energy homeostasis. It serves as a metabolic switch that regulates several intracellular systems including the cellular uptake of glucose, the beta-oxidation of fatty acids, and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.
The activation of AMPK has several benefits including enhancing insulin sensitivity which can be beneficial in managing type 2 diabetes mellitus. It also promotes weight loss and reduces fat storage by inhibiting the activity of acetyl CoA carboxylase (ACC), an enzyme that plays a crucial role in fatty acid synthesis and oxidation. Moreover, AMPK activation also appears to have anti-inflammatory effects and has been shown to reduce the expression of inflammatory markers.
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Cardiovascular Health: Studies have shown that the activation of AMPK by GLP-1 analog liraglutide can inhibit endothelial cell inflammation, thus providing cardiovascular benefits to patients with Type 2 diabetes [1].
Hypertension Treatment: The modulation of the AMPK/SIRT1/PGC-1α/FOXO3 pathway by bioactive peptides and exercise has been found to provide potential therapeutic benefits for hypertensive rats [2].
Lipid Metabolism Regulation: Atrial natriuretic peptide (ANP) has been shown to regulate lipid mobilization and oxygen consumption in human adipocytes by activating AMPK [3].
Longevity and Caloric Restriction: Adenosine nucleotide biosynthesis and AMPK have been found to regulate adult lifespan and mediate the longevity benefit of caloric restriction [4].
Diabetic Vascular Dysfunction Treatment: The wheat germ-derived peptide ADWGGPLPH has been demonstrated to serve as an antioxidant that provides benefits in the treatment of diabetic vascular dysfunction by modulating the PKCζ/AMPK/NOX4 pathway [5].
[1] https://pubmed.ncbi.nlm.nih.gov/24835252/
[2] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC9319799/
[3] https://pubmed.ncbi.nlm.nih.gov/21672517/
[4] https://pubmed.ncbi.nlm.nih.gov/23312286/
[5] https://www.researchgate.net/ publication/342454015
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://de.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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