IGF-1 LR3, or Insulin-like Growth Factor-1 Long R3, is a synthetic analog of the naturally occurring peptide hormone, IGF-1. It is engineered with an altered amino acid sequence, which includes an extended chain of 13 amino acids at the N-terminus and replacement of the Arg (R) for the Glu(E) at position three. These modifications enhance its biological activity by reducing binding to IGF-binding proteins (IGFBPs) and extending its half-life.
Research suggests IGF-1 LR3 plays a crucial role in muscle development and repair. By mimicking the action of insulin, it stimulates the uptake of nutrients into muscle cells and promotes protein synthesis, resulting in increased muscle mass and strength. Its longer half-life allows it to act over a more extended period, amplifying its effects on muscle growth.
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[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4665094/
[2] https://pubmed.ncbi.nlm.nih.gov/15240644/
[3] https://www.mdpi.com/ 1422-0067/24/3/2370
[4] https://pubmed.ncbi.nlm.nih.gov/10905488/
[5] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC5966339/
[6] https://pubmed.ncbi.nlm.nih.gov/34163008/
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