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Kisspeptin is a naturally occurring peptide hormone that stimulates the release of gonadotropin-releasing hormone (GnRH) during human reproduction. It is regarded as an important gatekeeper of sexual maturity, as its absence can result in delayed or absent puberty. Ongoing research suggests that Kisspeptin could be used to treat reproductive health disorders such as infertility and polycystic ovary syndrome.
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This product is intended for research purposes only. To be used by trained professionals only.
Kisspeptin, encoded by the KISS1 gene, is an important peptide hormone involved in human reproduction. It stimulates gonadotropin-releasing hormone (GnRH), regulating the release of luteinizing hormone and follicle-stimulating hormone, both of which are necessary for sexual maturation and function [1].
Kisspeptin functions via its receptor, GPR54, and has been discovered to have critical roles in the neuroendocrine regulation of reproduction. Deficiencies or mutations in Kisspeptin or GPR54 can result in pubertal failure and infertility, emphasising the relevance of these proteins in reproductive health [2].
Kisspeptin neurons also show different patterns of activity that are synchronised with the circadian rhythm, implying that they play a role in the timing of the preovulatory LH surge. This suggests that Kisspeptin pre mixed peptide may contribute to the LH surge by activating GnRH neurons [3].
The anatomy of the Kisspeptin neural network is complicated and ubiquitous in mammals, with varying distribution patterns across species. The structural and functional diversity of this network has been established in lower vertebrates and fish, showing its evolutionary conservation [4].
Interestingly, environmental factors can control the production and action of Kisspeptin, implying a role in seasonal reproduction. Changes in Kisspeptin peptide responses to peripheral injections have been observed in response to different environmental stimuli [5]. Research has also shown that Kisspeptin signalling can be synchronized and excited by high-frequency stimulation, highlighting its potential role in modulating reproductive rhythms. This finding opens up new avenues for understanding how Kisspeptin pre mixed peptide can regulate the reproductive system at the cellular and network levels.
[1] https://www.sciencedirect.com/ science/article/abs/pii/S00068993 10019992
[2] https://academic.oup.com/ humupd/article/12/5/631/7781 16
[3] https://onlinelibrary.wiley.com/ doi/abs/10.1111/j.1365-2826. 2011.02162.x
[4] https://academic.oup.com/ biolreprod/article/79/4/776/255 7727
[5] https://academic.oup.com/endo/ article/148/3/1158/2501844
Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH
Molecular Formula: C63H83N17O14
Molecular Weight: 1302.462 g/mol
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://de.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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