LL-37 Nasal Spray

Description

Buy LL-37 Nasal Spray

This product is intended for research purposes only. To be used by trained professionals only.

LL-37, also known as CAP-18, is a human peptide belonging to the cathelicidin family of antimicrobial peptides. It plays multiple roles in the human immune system, modulating innate immune responses, and preventing bacterial biofilm formation [1].

This multifunctional peptide can be up-regulated during an immune response. Its capabilities include protecting mice against lethal endotoxemia [2], indicating its potential for therapeutic applications in infections and sepsis. Moreover, it has been observed to prevent the formation of bacterial biofilms, which are structured communities of bacteria that contribute to chronic infections [3].

LL-37’s immunomodulatory role has been studied in the context of autoimmune diseases and viral infections. It has been found that both CD4+ and CD8+ LL-37-reactive T cells exist in patients with moderate-to-severe plaque psoriasis, suggesting that LL-37 nasal spray may influence the activation of these immune cells [4].

In addition to its immunomodulatory functions, research has demonstrated that LL-37 nasal spray peptide has angiogenic properties, promoting the growth of new blood vessels, mediated by formyl peptide receptor-like 1 expressed on endothelial cells [5]. This finding opens up potential avenues for therapeutic use in wound healing and tissue regeneration.

The interaction of LL-37 nasal spray with lipid bilayers has also been explored. Despite being highly charged, LL-37 interacts variably with lipid bilayers depending on their composition, which could influence its antimicrobial activity [6].

Interestingly, studies have shown that the LL-37 peptide can inhibit HIV-1 replication, suggesting potential applications in antiviral therapy. Furthermore, the antibacterial activity of LL-37 has been found to be conformation-dependent, providing insights into the structural basis of its function [7].

References:

[1] https://journals.aai.org/jimmunol/ article/191/10/4895/86783

[2] https://journals.aai.org/jimmunol/ article/169/7/3883/35412

[3] https://journals.asm.org/doi/full/ 10.1128/iai.00318-08

[4] https://www.mdpi.com/ 2076-393X/8/3/517

[5] https://www.jci.org/articles/ view/17545

[6] https://pubs.acs.org/doi/abs/ 10.1021/bi0273563

[7] https://www.jbc.org/article/ S0021-9258(18)93785-3/fulltext

Sequence: Leu Leu Gly Asp-Phe-Phe Arg Lys-Ser Lys-Glu Lys.11e-Gly Lys Glu Phe Lys-Arg Ile Val-Gln Are Ile-Lys Asp Phe Leu Arg Asn Leu Val Pro-Arg Thr-Glu-Ser

Molecular Formula: C205 H340 N60 O53

Molecular Weight: 4493.342 g/mol

Storage: Lyophilized peptides to be stored below -18°C

Research use only. Not for human or animal consumption!

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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://de.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.

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