Tripeptide-29 (Topical)

Description

Tripeptide-29 200mg (Topical Peptide)

This product is intended for research purposes only. To be used by trained professionals only.

An artificial version of a collagen building block is called tripeptide-29. The peptide, which is three amino acids long, resembles the typical Gly-Pro-X/Gly-X-Hyp structure found in collagen subunits.

Tripeptide-29 essentially functions as a component of bigger collagen molecules. In doing so, it can alter the tertiary and quaternary characteristics of a collagen molecule due to its amino acid sequence and relative frequency with the collagen superstructure. Collagen functions in cell adhesion, tissue control, and healing in addition to being a structural protein. Tripeptide-29 may therefore affect a wide range of physiological characteristics.

Clinical studies have found that Tripeptide-29 is a partial agonist of the collagen receptor GPVI in its non-polymerized form. The surface of platelets, which resemble cells and are in charge of the initial development of blood clots, expresses GPVI. The GPVI receptor is essential for the collagen-induced stimulation of platelet aggregation in vascular tissue, which is the initial stage of tissue healing and clot formation. Collagen fibres are therefore typically thought to be thrombogenic [1].

Short peptides, such as tripeptide-29, have been shown to play a function in modulating the stability of collagen according to research. Scientists have learned that the final peptide in a tripeptide monomer has the greatest influence on the final structure of collagen. The tripeptide-29 located at position C in an A-B-C monomer has the greatest impact on the ultimate stability of collagen [2]. This discovery may eventually aid in the development of artificial implants for teeth, bone, cartilage, and other tissues.

The function of tripeptide-29 and other tripeptides in shielding skin against the ageing process is gaining attention lately. According to studies conducted on animals, applying topical tripeptides can improve skin texture, reduce the appearance of fine lines and wrinkles, and increase hydration, all of which can reduce the signs of ageing on the skin. Tripeptides have also been shown to improve the texture of skin including skin pigmentation abnormalities. In studies 90% of research participants displayed enhanced skin hydration as well as higher flexibility as a result of improved elasticity[6].

Topical tripeptide-29 can increase skin turnover and lessen fine wrinkles, crow’s feet, under-eye bags, and hollowing around the eyes when paired with specific hexapeptides.

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References:

[1] Monomeric (glycine-proline-hydroxyproline)10 repeat sequence is a partial agonist of the platelet collagen receptor glycoprotein VI. Biochem J. 1999 Apr 15;339 ( Pt 2)(Pt 2):413-8. by Asselin J, Knight CG, Farndale RW, Barnes MJ, Watson SP.

[2] Effects of terminal tripeptide units on mechanical properties of collagen triple helices, Extreme Mechanics Letters
Volume 64, November 2023, 102075 by Milad Masrouri, Zhao Qin

[3] Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study. Clin Cosmet Investig Dermatol. 2017 Nov 13;10:473-482. by Garre A, Martinez-Masana G, Piquero-Casals J, Granger C.

Molecular formula: C12H19N3O5

Molecular weight: 285.30 g/mol

ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.

DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://de.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.

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